ABSTRACT
Ikehara S, Iso H, Date C, Kikuchi S, Watanabe Y, Wada Y, Inaba Y,
Tamakoshi A; JACC Study Group
STUDY OBJECTIVES: To examine sex-specific associations
between sleep duration and mortality from cardiovascular disease and other
causes.
DESIGN: Cohort study.
SETTING: Community-based study.
PARTICIPANTS: A total of 98,634 subjects (41,489 men and
57,145 women) aged 40 to 79 years from 1988 to 1990 and were followed until
2003.
INTERVENTIONS: N/A.
MEASUREMENTS AND RESULTS: During a median follow-up of
14.3 years, there were 1964 deaths (men and women: 1038 and 926) from stroke,
881 (508 and 373) from coronary heart disease, 4287 (2297 and 1990) from
cardiovascular disease, 5465 (3432 and 2033) from cancer, and 14,540 (8548 and 5992)
from all causes. Compared with a sleep duration of 7 hours, sleep duration of 4
hours or less was associated with increased mortality from coronary heart
disease for women and noncardiovascular disease/noncancer and all causes in
both sexes. The respective multivariable hazard ratios were 2.32 (1.19-4.50)
for coronary heart disease in women, 1.49 (1.02-2.18) and 1.47 (1.01-2.15) for
noncardiovascular disease/noncancer, and 1.29 (1.02-1.64) and 1.28 (1.03-1.60)
for all causes in men and women, respectively. Long sleep duration of 10 hours
or longer was associated with 1.5- to 2-fold increased mortality from total and
ischemic stroke, total cardiovascular disease, noncardiovascular
disease/noncancer, and all causes for men and women, compared with 7 hours of
sleep in both sexes. There was no association between sleep duration and cancer
mortality in either sex.
CONCLUSIONS: Both short and long sleep duration were
associated with increased mortality from cardiovascular disease,
noncardiovascular disease/noncancer, and all causes for both sexes, yielding a
U-shaped relationship with total mortality with a nadir at 7 hours of sleep. (Sleep. 2009 Mar;32(3):295-301)
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