ABSTRACT
Tom Van
Herpe, Ph.D. and Dieter Mesotten, M.D., Ph.D.
Studies on tight glycemic control
by intensive insulin therapy abruptly changed the climate of limited interest in
the problem of hyperglycemia in critically ill patients and reopened the
discussion on accuracy and reliability of glucose sensor devices. This article
describes important components of blood glucose measurements and
their interferences with the focus
on the intensive care unit setting. Typical methodologies, organized from analytical
accuracy to clinical accuracy, to assess imprecision and bias of a glucose
sensor are also discussed. Finally, a list of recommendations and requirements
to be considered when evaluating (time-discrete) glucose sensor devices is
given.
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